This website contains information about
INBRIJA® (levodopa inhalation powder)
M-INB-UK-0047
Date of preparation: December 2025
When to consider
on-demand treatment
During an OFF episode, patients can add on-demand therapy to baseline therapy to bring improvement quickly when:1
Changes in maintenance regimens do
not reliably eliminate symptom return
Meals or gut motility problems interfere
with administration of oral levodopa
Symptoms return unexpectedly
or unpredictably
Onset of action is too slow with oral dose,
contributing to morning OFF episodes,
as effect wears off overnight
ON-demand therapy as a complementary treatment in managing OFF episodes
OFF episodes may occur even with optimised baseline and adjunctive therapy.2
Adapted from Isaacson SH et al. Clin Park Relat Disord. 2022;7:1001612
On-demand treatment of OFF
episodes can:2
- Rapidly restore motor function to ON
- Bridge treatment gaps without adjusting baseline regimen
- Strengthen patient confidence in managing their daily lives
References:
- 1. Hauser RA, Isaacson SH, Ellenbogen A, et al. Orally inhaled levodopa (CVT-301) for early morning OFF periods in Parkinson’s disease. Parkinsonism Relat Disord. 2019;54:175-180.
- 2. Isaacson SH, et al. Clin Park Relat Disord. 2022;7:100161.